HKU Division of Joint Replacement Surgery

Redefining Orthopaedics with
Artificial Intelligence

Pioneering the intersection of Biomechanics, Computer Vision, and Surgical Robotics.

Department Profile

The University of Hong Kong

Dr. Lawrence Lau MBChB, MRCSEd, FRCSEd(Orth), FHKAM (Orthopaedic Surgery), PhD

Dr. Lau is a Clinical Assistant Professor at the University of Hong Kong. An active surgeon and researcher, he is bridging clinical orthopaedics with AI, imaging, and engineering-driven innovation.

Gold Medal with Congratulation of the Jury

2023 International Exhibition of Inventions Geneva

David Fang Trophy

Best Specialist Paper in Adult Joint Reconstruction, HKOA

Google Scholar Contact

Research Focus

Where AI meets Clinical Practice.

AI & Health Informatics

Machine learning for loosening detection & clinical decision making.

Advanced Imaging (MARS)

Multi-energy spectral photon-counting CT for implant failure analysis.

Robotics & Biomechanics

Robotic assisted surgery and Finite Element Analysis (FEA).

Periprosthetic Infection

Diagnosis and management of complex joint infections.

Osteoporosis & Sarcopenia

Addressing musculoskeletal aging challenges.

Arthroplasty Design

Survival analysis and next-gen implant design.

Selected Publications

Recent papers spanning rehabilitation, optimization, robotics, wound care, and AI.

View Google Scholar

Recent highlights

AI & Deep Learning 2026

A Disease-Aware Dual-Stage Framework for Chest X-ray Report Generation

P Wu, H Dong, Y Lin, Y Ding, Y Peng | AAAI 2026

AI & Medical Imaging 2026

A novel deep learning based automatic ultrasonic posterior cruciate ligament clinical assessment tool

JP Kao, J Zhang, WN Lee, CP Chen, LCM Lau | npj Artificial Intelligence

Implant Design 2026

Personalization and Precision: Innovative Applications and Future Challenges of Additive Manufacturing in Orthopedic Implants

P Wu, X Liu, Z Guo, L Lau | Journal of Orthopaedic Research

Medical AI 2025

AMD-Mamba: A Phenotype-Aware Multi-Modal Framework for Robust AMD Prognosis

P Wu, M Lin, Q Chen, EY Chew, Z Lu, Y Peng, H Dong | MICCAI Workshop 2025

Implant Survival 2025

Cementless acetabular component without screw holes with immediate full weightbearing: a minimum 20-year follow-up study

LCM Lau, KY Wong, H Hu, MH Cheung, FY Ng, H Fu, PK Chan, KY Chiu | Bone & Joint Open

Health Systems 2025

Current status of Asian joint registries: a review

BCP Shum, LCM Lau, JPY Cheung, SW Choi | EFORT Open Reviews

Optimization 2024

Preoperative weight loss interventions before total hip and knee arthroplasty: a systematic review of randomized controlled trials

Lau LCM, Chan PK, Lui TWD, et al. | Arthroplasty

Infection & Immunity 2024

Blockade of endothelin receptors mitigates SARS-CoV-2-induced osteoarthritis

MT Au, J Ni, K Tang, W Wang, L Zhang, H Wang, F Zhao, Z Li, P Luo, et al. | Nature Microbiology

Digital Pathology 2024

Aligning knowledge concepts to whole slide images for precise histopathology image analysis

W Zhao, Z Guo, Y Fan, Y Jiang, MCF Yeung, L Yu | npj Digital Medicine

Wound Care 2023

Single use Negative Pressure Wound Therapy (NPWT) system in the management of knee arthroplasty

Chau WW, Lo KCH, Lau LCM, et al. | BMC Musculoskeletal Disorders

Robotics 2023

Surgical accuracy and clinical outcomes of image-free robotic-assisted total knee arthroplasty

Cyrus TK Lau, Chau WW, Lau LCM, et al. | International Journal of Medical Robotics

Medical AI 2023

An improved Yolov5s based on transformer backbone network for detection and classification of bronchoalveolar lavage cells

P Wu, H Weng, W Luo, Y Zhan, L Xiong, H Zhang, H Yan | Computational and Structural Biotechnology Journal

AI & Deep Learning 2022

A novel image-based machine learning model with superior accuracy and predictability for knee arthroplasty loosening detection and clinical decision making

Lau LCM, Chui ECS, Man GCW, et al. | Journal of Orthopaedic Translation

Advanced Imaging 2021

Multi-energy spectral photon-counting computed tomography (MARS) for detection of arthroplasty implant failure

LCM Lau, WYW Lee, APH Butler, AI Chernoglazov, KY Chung, KKW Ho, J Griffith, PH Butler, PSH Yung | Scientific Reports

Knee Osteoarthritis 2021

Satisfactory long-term survival, functional and radiological outcomes of open-wedge high tibial osteotomy for managing knee osteoarthritis: Minimum 10-year follow-up study

LCM Lau, JCH Fan, KY Chung, KW Cheung, GCW Man, YW Hung, CKB Kwok, KKW Ho, KH Chiu, PSH Yung | Journal of Orthopaedic Translation

View Full List on Google Scholar

The Team

Driving Innovation.

Ziyu Guo

PhD Student

Focus: Biomechanics & Design

Puzhen Wu